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KMID : 0942820060050020092
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Journal of Korean Brain Tumor Society
2006 Volume.5 No. 2 p.92 ~ p.95
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Genetic Alterations in Meningiomas
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Sim Jong-Eun
Sung Soon-Ki
Song Young-Jin
Kim Dae-Chul
Han Jin-Yeong
Choi Sun-Seob
Kim Ki-Uk
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Abstract
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Objective: Brain tumors develop by genetic alterations at gene level. Genetic alteration may be different according to each tumor and subtype. Even though major genetic alterations for the particular tumors are known, there are many minor genetic alterations for the tumors. Authors designed the study in order to see the difference in the genetic profile of meningiomas.
Methods: 16 patients of meningioma were operated between Jun 2004 and May 2005. Surgical specimens were prepared for chromosomal study and karyotyping was done by traditional G-banding method.
Results: Chromosome abnormalities have been observed in many cases in meningiomas. In meningiomas, loss of chromosome 22 was the most common, and other abnormalities were translocation between the long arm of chromosome 13 and 22, whole arm translocation between the chromosome 1 and 19, loss of Y chromosome and hyperdiploidy and monosomies for various chromosome.
Conclusion: Chromosomal abnormalities seem to be variable and genetic changes are present in meningioma.
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KEYWORD
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Chromosome, Gene analysis, Meningioma
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